An infusion of iron-dextran diluted in 1000 ml of physiologic saline solution was given to 51 patients. The average Hb response was 1.9 g/dl per wk. Mean corpuscular volume, mean corpuscular Hb concentration and mean corpuscular Hb deficits also were corrected. There were no allergic reactions. This is an extremely reliable and safe method of replenishing depleted Fe in patients.