Block of a glioma cell line in S by interferon
- 15 June 1981
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 27 (6), 749-754
- https://doi.org/10.1002/ijc.2910270604
Abstract
The human glioma cell line U-251 MG, with a well-characterized defect in growth control, was sensitive to the antiproliferative effects of human (fibroblast) interferon (IFN). IFN inhibited exponentially growing cells by increasing the number of cells in the S stage of the cell cycle. At the same time the number of cells in G0/G1 diminished. The rate of thymidine incorporation was decreased during the first cell cycle, with no prolongation of S. However, in synchronized cultures, the wave of cells with a S-phase content did not decrease over a time period several hours longer than the length of S measured by pulse labelling. Thus we conclude that, at a sufficient dose, the cells were unable to accomplish cell division as they prematurely stopped synthesizing DNA.This publication has 26 references indexed in Scilit:
- Growth Inhibition by IFN Achieved by Collecting Cells in G0Journal of Interferon Research, 1982
- The structure of one of the eight or more distinct chromosomal genes for human interferon-αNature, 1980
- Two candidate G1 polypeptides in chick embryo fibroblastsJournal of Cellular Physiology, 1980
- Inhibitors of RNA synthesis and passage of chick embryo fibroblasts through the G1 periodJournal of Cellular Physiology, 1980
- Interferon effects on the growth and division of human fibroblastsExperimental Cell Research, 1979
- Effects of Leukocyte and Fibroblast Interferon on Events in the Fibroblast Cell CycleJournal of General Virology, 1979
- Effect of Interferon on the Cell Cycle of BALB/c 3T3 CellsJournal of General Virology, 1978
- Interferon suppresses the transition of quiescent 3T3 cells to a growing stateNature, 1977
- Effects of Interferon on the Human Clonal Cell Line, RSa: Inhibition of Macromolecular SynthesisJournal of General Virology, 1976
- Serum stimulation of stationary human glia and glioma cells in cultureExperimental Cell Research, 1975