Antagonism of Dicumarol by Vitamin K Preparations

Abstract

DICUMAROL is of proved value in the prophylaxis and treatment of thromboembolic disease. In recent years it has come into general clinical usage. The narrow margin between a clinically effective prothrombin level and the prothrombin level at which bleeding occurs imposes a certain hazard in treatment. Even with the most careful management of Dicumarol therapy, an unsuspected complication such as an asymptomatic peptic ulcer may result in fatal hemorrhage. The literature attests the seriousness of such bleeding in patients treated with Dicumarol.^{1 2 3 4} In event of hemorrhage it is of the utmost importance to remedy quickly the coagulation defect produced by . . .