Three-year survey of amikacin use and aminoglycoside resistance in a general hospital in Belgium
- 1 April 1988
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Microbiology & Infectious Diseases
- Vol. 7 (2), 183-185
- https://doi.org/10.1007/bf01963076
Abstract
The aim of the study was to evaluate the effect of intensive use of amikacin on the resistance levels to amikacin, gentamicin, tobramycin, netilmicin and dibekacin. The base-line resistance in the preamikacin phase (three months of amikacin use less than 1 %; 676 isolates) was 1.0 % for amikacin, 11.4 % for gentamicin, 8.0 % tobramycin, 6.2 % for netilmicin and 8.3 % for dibekacin. During the amikacin phase (36 months of average amikacin use of 89 %; 6048 isolates) there was no significant change in aminoglycoside resistance except for dibekacin (from 8.3 % to 10.9 %, 0.05>p>0.02). Isolated amikacin resistance was not observed.This publication has 17 references indexed in Scilit:
- Clinical Response to Aminoglycoside Therapy: Importance of the Ratio of Peak Concentration to Minimal Inhibitory ConcentrationThe Journal of Infectious Diseases, 1987
- Frequency of aminoglycoside 6'-N-acetyltransferase among Serratia species during increased use of amikacin in the hospitalAntimicrobial Agents and Chemotherapy, 1986
- Resistance surveillance programs and the incidence of gram-negative bacillary resistance to amikacin from 1967 to 1985American Journal Of Medicine, 1986
- A One Year Survey on the Epidemiology of Aminoglycoside Resistance in a General Hospital: Influence of Amikacin.Acta Clinica Belgica, 1986
- Aminoglycoside resistance in gram-negative bacilli during increased amikacin use: Comparison of experience in 14 United States hospitals with experience in the Minneapolis Veterans Administration Medical CenterAmerican Journal Of Medicine, 1985
- Progressive Increase in Antibiotic Resistance of Gram-negative Bacterial IsolatesArchives of Internal Medicine, 1983
- Resistance of gram-negative bacilli as related to hospital use of antimicrobial agentsAntimicrobial Agents and Chemotherapy, 1983
- CEFOXITIN, AMIKACIN, AND PSEUDOMONAS AERUGINOSA RESISTANCEThe Lancet, 1982
- Epidemiological studies of aminoglycoside resistance in the U.S.A.Journal of Antimicrobial Chemotherapy, 1981
- Relationship between antibiotic consumption and frequency of antibiotic resistance of four pathogens—a seven-year surveyJournal of Antimicrobial Chemotherapy, 1976