ConStruct: Improved construction of RNA consensus structures
Open Access
- 28 April 2008
- journal article
- Published by Springer Nature in BMC Bioinformatics
- Vol. 9 (1), 219
- https://doi.org/10.1186/1471-2105-9-219
Abstract
Aligning homologous non-coding RNAs (ncRNAs) correctly in terms of sequence and structure is an unresolved problem, due to both mathematical complexity and imperfect scoring functions. High quality alignments, however, are a prerequisite for most consensus structure prediction approaches, homology searches, and tools for phylogeny inference. Automatically created ncRNA alignments often need manual corrections, yet this manual refinement is tedious and error-prone.Keywords
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