Perianal paget's disease

Abstract

Summary Diagnosis must be established by adequate biopsy. Preferably the area bearing apocrine glands and showing even the mildest eczematoid change should be excised and examined microscopically. It should be emphasized that “Pagetoid formation” and Paget’s cellsin situ on underlying cancer is an extremely serious condition because of the tendency to become complicated by general carcinomatosis even when extramammary Paget’s disease appears to have been cured by surgical removal. Terminology should be changed from extramammary Paget’s disease to Paget’s disease of the area involved if the condition is similar to Paget’s disease of the nipple. Also, it should be understood that the lesion is an intra-epithelial cancer and not a precancerous dermatose. Treatment consists of wide and deep removal of all involved tissue.