Recent Advances in HPLC Analysis of Analgesics

Abstract

Recent developments in HPLC analysis of analgesics have been rapid, paralleling the growth of chromatographic sciences as a whole. Although analgesics have been used for hundreds of years and chromatgraphic separations have been carried out on them for decades, liquid chromatographic analysis of analgesics has advanced most rapidly in the past 5–7 years . The present review will focus on applications of HPLC to the analysis of commercial analgesics in this time period with emphasis on novel developments and applications associated with the improved accuracy, sensitivity and specificity in herent in current LC systems.