MORPHINE AND HISTAMINE RELEASE
- 1 September 1958
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 10 (1), 22-29
- https://doi.org/10.1111/j.2042-7158.1958.tb10269.x
Abstract
A wide range of drugs exert analeptic action in dogs treated with morphine; cyclizine, diphenhydramine, chlorcyclizine, Avil, tripelennamine and succinic acid. Benactyzine and Pacatal are without effect. Histamine and an antihistaminase (isoniazid) exert some alerting action in a morphine-treated dog. Morphine induces the signs of histamine release in some dogs. Histamine itself reproduces some of the side effects of morphine. Histamine-treated dogs appear to be analgesic. Rabbits and dogs, behaved similary but cats were different and variable when given antihistamine drugs after morphine. Some of the side actions of morphine are mediated by histamine release.Keywords
This publication has 8 references indexed in Scilit:
- Further Experience with Amiphenazole and Morphine in Intractable PainBMJ, 1956
- MORPHINE ANTAGONISMImmunology & Cell Biology, 1955
- THE PHARMACOLOGY OF SOME NEW ANTI‐CHOLINESTERASESImmunology & Cell Biology, 1953
- Pethidine and the Triple ResponseBMJ, 1953
- Morphine AntagonismNature, 1952
- Release of histamine from skin and muscle in the cat by opium alkaloids and other histamine liberatorsThe Journal of Physiology, 1951
- The responses of the heart rate and the systolic blood pressure to a series of sympathomimetic amines in the unanaesthetized, atropinized bitchThe Journal of Physiology, 1950
- The site of action of narcotics in respiratory processesBiochemical Journal, 1941