Cyclic AMP in Cerebrospinal Fluid of Rats: Effects of Electroconvulsive Shock

Abstract

The concentration of cyclic[c]AMP was measured in cisternal CSF of male and female rats after electroconvulsive shock [an animal analogue of epileptic seizures]. cAMP levels were increased, compared to sham-treated controls, for several hours following electroconvulsive shock with maximal increases of 46.8% in male and 17.2% in female rats. Old rats (300-360 g body wt) showed higher baseline concentrations than younger rats (180-250 g). In both groups female rats tended to have higher cAMP levels than male rats.