Dependence of the cytostatic effect of adriamycin on drug concentration and exposure time in vitro
- 1 June 1980
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 41 (6), 886-891
- https://doi.org/10.1038/bjc.1980.165
Abstract
The surviving fraction (SF) of Chinese hamster cells and HeLa cells after treatment with a range of Adriamycin concentrations and exposure times was determined. The cytostatic effect was proportional to the product of extracellular drug concentration (c) and exposure time (t) according to the equation: sf=e-ktc. By determining the intracellular drug concentration at various exposures, it could be shown that absorbed dose is not proportional to exposure dose.Keywords
This publication has 11 references indexed in Scilit:
- The Concept of Drug Dose for in Vitro Studies with Chemotherapeutic AgentsRadiation Research, 1978
- DISTRIBUTION AND ANTI-TUMOR ACTIVITY OF ADRIAMYCIN GIVEN IN A HIGH-DOSE AND A REPEATED LOW-DOSE SCHEDULE TO MICE1978
- Comparative chemosensitivity of exponential- versus plateau-phase cells in both in vitro model systems.1976
- Clinical effects and pharmacokinetics of different dosage schedules of adriamycin.1976
- Adriamycin—A ReviewJNCI Journal of the National Cancer Institute, 1975
- Adriamycin chemotherapy—efficacy, safety, and pharmacologic basis of an intermittent single high-dosage scheduleCancer, 1974
- Survival kinetics of cultured human lymphoma cells exposed to adriamycin.1973
- A fluorometric assay for daunomycin and adriamycin in animal tissuesBiochemical Medicine, 1973
- Survival and cell kinetics effects of adriamycin on mammalian cells.1973
- Implications of biochemical, cytokinetic, pharmacologic, and toxicologic relationships in the design of optimal therapeutic schedules.1970