A SPECIFIC MODIFICATION OF LEUCYL-sRNA OF ESCHERICHIA COLI AFTER PHAGE T2 INFECTION
- 1 December 1964
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 52 (6), 1535-1540
- https://doi.org/10.1073/pnas.52.6.1535
Abstract
A specific structural modification of leucyl-sRNA of E. coli B upon phage T2 infection was discovered by methylated albumin column fractionation of aminoacyl-sRNA. Among 17 amino acids examined (all except asparagine, glutamine, and cysteine), only one or two components of leucyl-sRNA showed a clear alteration after the phage infection. The modification started at the 3rd minute after infection and was completed by the 8th minute. The injection of phage DNA and protein synthesis were required for the modification. The possible implication of the modification on the transition of protein synthesis from the early to the late phase has been discussed.Keywords
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