Deuterium Isotope Effect on the Carcinogenicity of Dimethylnitrosamine in Rat Liver 2

Abstract

Liver tumor incidence was 26% in male MRC rats receiving 5 parts per million (ppm) dimethylnitrosamine in their drinking water for 30 weeks. A significantly different liver tumor incidence of 3% was observed in a second group of rats receiving fully deuterated dimethylnitrosamine under identical condition.