Supersensitivity of the Cat Heart to Catecholamine-Induced Arrhythmias Following Reserpine Pretreatment.
- 1 November 1962
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 111 (2), 484-486
- https://doi.org/10.3181/00379727-111-27830
Abstract
The threshold doses of norepinephrine and epinephrine producing ventricular arrhythmias were determined in spinal (pithed) cats. Of 20 control cats, only 2 had norepinephrine thresholds of 3 [mu] g/kg or below while among 27 cats treated with reserpine 0.1 mg/kg/day for 7 to 28 days 13 had thresholds of 3 [mu]/kg or below (P = .02). In the case of epinephrine, 3 of 10 control cats had thresholds of 30 [mu]g/kg or below, whereas 19 of 26 cats treated with reserpine were within the range (P = .05). There was indication of increasing sensitivity to catecholamine-induced arrhythmias with increasing duration of reserpine pretreatment.Keywords
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