Further evidence of response by leukaemia patients in remission to antigen(s) related to acute myelogenous leukaemia
Open Access
- 1 March 1977
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 35 (3), 273-279
- https://doi.org/10.1038/bjc.1977.39
Abstract
Fifteen patients with acute myelogenous leukaemia were studied to determine if their remission blood leucocytes could be stimulated into taking up [3H] thymidine after in vitro culture with their own cryo-preserved irradiated AML leukaemia cells. In 6/15 patients it was possible to show autologous recognition and equal recognition of their stored leukaemia cells, even when they had previously been maintained in in vitro proliferative cultures in liquid suspension and undergoing myeloid maturation for one week. After in vitro proliferative culture, 4 populations of leukaemia cells produced material in the supernatant media between 3 and 7 days capable of inducing [3H] thymidine uptake in autologous (2 pts, 5 supernatants) and allogeneic (2 pts, 2 supernatants) AML remission lymphocytes, but not in normal donor lymphocytes. The relevance of these observations to tumour-associated AML antigen is discussed.Keywords
This publication has 11 references indexed in Scilit:
- Detection of Monocyte Specific Antigen on Human Acute Leukaemia CellsBritish Journal of Haematology, 1976
- Human Leukemia-Associated Antigens: Detection on Cells of Established Lymphoblastoid LinesThe Journal of Immunology, 1975
- Safe Method of Collecting Leukaemia Cells from Patients with Acute Leukaemia for Use as ImmunotherapyBMJ, 1974
- Human Leukemia Cell Antigens: Serologic Characterization With Xenoantisera2JNCI Journal of the National Cancer Institute, 1974
- Spontaneous shedding of TSTA by viable sarcoma cells: its possible role in facilitating metastatic spreadBritish Journal of Cancer, 1974
- Immunotherapy for Acute Myelogenous LeukaemiaBritish Journal of Cancer, 1973
- Recognition of Leukaemia Cells as Foreign before and after AutoimmunizationBMJ, 1971
- Production and Specificity of a Blastogenic Factor in Mixed Leucocyte Cultures from Twin SistersNature, 1970
- RESPONSE OF HUMAN BLOOD LYMPHOCYTES TO TUBERCULIN PPD IN TISSUE CULTURE1967