Rubbish in the Red Cell

Abstract

The role of the erythrocyte is simple and uncomplicated: it transports oxygen and carbon dioxide in the blood. To accomplish this gaseous transfer, the erythrocyte must traverse capillaries no greater than its own diameter and sometimes even smaller. Passage through some of these straitened gates requires that the cell fold upon itself, elongate or assume the form of a parachute.¹ Obviously, the cell must remain plastic and flexible to achieve these alterations in shape without rupture. Therefore, the flow characteristics of the intracellular solution of hemoglobin and enzymes must not be disturbed by the presence of concretions. The membrane itself . . .