Inhibition of oxidative enzymes by anti-allergy drugs
- 1 November 1981
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 11 (5), 503-509
- https://doi.org/10.1007/bf02004713
Abstract
Lodoxamide tromethamine and several other antiallergy drugs, i.e. inhibitors of rat passive cutaneous anaphylaxis, are inhibitors of purified xanthine oxidase. Inhibition is noncompetitive withK i's in the 1–13 micromolar range. Lodoxamide tromethamine had no effect on another flavoprotein, glucose oxidase. Other studies have shown several of these drugs are inhibitors of aldose reductase. It is speculated that the anti-allergy drugs inhibit mediator release from mast cells by blocking univalent electron transfers which are essential for release.This publication has 32 references indexed in Scilit:
- Inhibition by quercetin of activation of polymorphonuclear leucocyte functions Stimulus-specific effectsBiochimica et Biophysica Acta (BBA) - Biomembranes, 1980
- Aldose reductase in diabetic complications of the eyeMetabolism, 1979
- Xanthine oxidase-induced histamine release from isolated rat peritoneal mast cells: involvement of hydrogen peroxideBiochemical Pharmacology, 1979
- Differences in the Susceptibility of Various Aldose Reductases to InhibitionPublished by Springer Nature ,1979
- Structure-activity studies of aldose reductase inhibitors containing the 4-oxo-4H-chromen ring systemBiophysical Chemistry, 1978
- Immunologic and Nonimmunologic Generation of Superoxide from Mast Cells and BasophilsJCI Insight, 1978
- Inhibition of Allergic Reactions by Cromoglycate and by a New Antiallergy Drug U-42,585EInternational Archives of Allergy and Immunology, 1978
- Inhibition of Allergic Reactions by Cromoglycate and by a New Anti-Allergy Drug U-42,585EInternational Archives of Allergy and Immunology, 1978
- Inhibition of urate production by allopurinolBiochemical Pharmacology, 1977
- Chemistry and Biochemistry of Xanthine OxidasePublished by Wiley ,1956