Epidermal Changes in Lichen Planus
- 1 August 1976
- journal article
- research article
- Published by Wiley in Journal of Cutaneous Pathology
- Vol. 3 (4), 167-174
- https://doi.org/10.1111/j.1600-0560.1976.tb00858.x
Abstract
Ultrastructural investigations in 15 patients with lichen planus (LP) revealed a multitude of epidermal changes. The most consistent findings were multiplication, irregular folding or dislocation of the basal lamina; fragmentation with degenerative changes of basal keratinocytes; formation of numerous fibrillar Civatte bodies and presence of dyskeratotic elements. In addition, mitotic finures of keratinocytes and Langerhans cells were observed. The primary event in LP probably represents an injury involving epidermal basal cells. The replacement of destroyed tissue seemed to originate not only from the margin of the lesions or the skin appendages but also from unaffected cells within the LP papule.This publication has 24 references indexed in Scilit:
- Epidermal Changes in Lichen PlanusJournal of Cutaneous Pathology, 1976
- Epidermal cell kinetics in lichen planus*British Journal of Dermatology, 1973
- Nuclear bodies in oral lichen planusJournal of Ultrastructure Research, 1972
- The role of the epidermis in the histopathogenesis of lichen planus. Histochemical correlationsArchives of Dermatology, 1972
- Light and electron microscopic studies of colloid bodies in lichen planusJournal of Periodontal Research, 1970
- The ultrastructure of the epidermis in lichen ruber planus as revealed by electron microscopy: II. Cytoplasm and nucleus in certain basal and spinous cellsJournal of Ultrastructure Research, 1969
- The ultrastructure of the epidermis in lichen ruber planus as revealed by electron microscopy: I. Dermo epidermal junction, stratum basale, and lower stratum spinosumJournal of Ultrastructure Research, 1969
- Ultrastructural observations on lichen planusArchives of Dermatology, 1967