CORRELATION AND PROGNOSTIC SIGNIFICANCE OF p53, p21 WAF1/CIP1 AND Ki-67 EXPRESSION IN PATIENTS WITH SUPERFICIAL BLADDER TUMORS TREATED WITH BACILLUS CALMETTE-GUERIN INTRAVESICAL THERAPY
- 1 March 1999
- journal article
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 161 (3), 792-798
- https://doi.org/10.1016/s0022-5347(01)61770-1
Abstract
Conclusions Our results indicate that p21 WAF-1-CIP1 seems to be regulated by p53 independent pathways in superficial bladder cancer. The present study did not indicate an independent prognostic significance in patients treated with BCG for p53, p21 WAF-1-CIP1 or Ki-67 markers. Larger prospective studies are needed to evaluate further the independent value of these biological markers in superficial bladder cancer management.Keywords
This publication has 22 references indexed in Scilit:
- Humoral response against heat shock proteins and other mycobacterial antigens after intravesical treatment with bacille Calmette–Guérin (BCG) in patients with superficial bladder cancerClinical and Experimental Immunology, 1997
- Long-Term Efficacy of Intravesical Bacillus Calmette-Guerin for Carcinoma in Situ: Relationship of Progression to Histological Response and p53 Nuclear AccumulationJournal of Urology, 1997
- Relationship between abnormal p53 protein and failure to express p21 protein in human breast carcinomasThe Journal of Pathology, 1997
- Evolution and Clinical Significance of the T Cell Proliferative and Cytokine Response Directed Against the Fibronectin Binding Antigen 85 Complex of Bacillus Calmette-Guerin During Intravesical Treatment of Superficial Bladder CancerJournal of Urology, 1997
- The relevance of p53 mutation in urological malignancies: possible clinical implications for bladder cancerBJU International, 1996
- Cell-cycle control and its watchmanNature, 1996
- Urinary Cytokines During Intravesical Bacillus Calmetteguerin Therapy for Superficial Bladder Cancer: Processing, Stability and Prognostic ValueJournal of Urology, 1996
- Cancer progression and p53The Lancet, 1995
- Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint controlCell, 1995
- p53 but not erbB-2 expression is associated with rapid tumor proliferation in urinary bladder cancerHuman Pathology, 1994