Possibility of a viral etiology in recurrent aphthous ulcers and Behçet's syndrome
- 1 November 1978
- journal article
- Published by Wiley in Journal of Oral Pathology & Medicine
- Vol. 7 (6), 353-364
- https://doi.org/10.1111/j.1600-0714.1978.tb01602.x
Abstract
The clinical signs, laboratory data, and histological features of recurrent aphthous ulcers (RAU) and Behçet's syndrome suggest a viral etiology. In fact, there are reports of adenovirus isolations in herpetiform oral ulcers and on the isolation of a filterable agent in sporadic cases of Behçet's syndrome. However, isolation studies on the major and minor aphthous ulcers and more recent studies on Behçet's syndrome have been negative. A review of the literature on the role of viruses and autoimmunity in RAU and Behçet's syndrome is presented. Biopsy specimens of ulcerative lesions were grown in vitro for up to 300 days. Those cultures, along with leukocytes and body fluids, were examined by a variety of techniques for the presence of virus or viral antigens. Although a persistent or latent virus was not detected, these negative studies cannot exclude a viral etiology. In fact, the hypothesis of an infectious and viral etiology is still reasonable.Keywords
This publication has 45 references indexed in Scilit:
- Immunological aspects of recurrent oral ulceration and Behçet's syndromeJournal of Oral Pathology & Medicine, 1978
- Determination of Serum C9 Level by ImmunodiffusionInternational Archives of Allergy and Immunology, 1975
- AN IMMUNOFLUORESCENCE STUDY ON THE HUMORAL IMMUNITY TO ADULT HUMAN ORAL MUCOSA IN RECURRENT APHTHOUS STOMATITISAllergy, 1974
- Adenovirus Isolation from Recurrent Oral UlcersThe Journal of Periodontology, 1973
- Persistence of Viruses of Kuru and Creutzfeldt-Jakob Disease in Tissue Cultures of Brain CellsNature, 1972
- A Possible Pathogenic Role for Virus-Carrier LymphocytesThe Journal of Infectious Diseases, 1971
- MIKULICZ'S RECURRENT ORAL APHTHAE HISTOPATHOLOGICAL COMPARISON WITH 2 EXPERIMENTALLY INDUCED IMMUNOLOGICAL REACTIONSBritish Journal of Dermatology, 1970
- Mikulicz's recurrent oral aphthae. The effect of hydrocortisone succinate sodium upon the in vitro lymphocyte cytotoxicityBritish Dental Journal, 1970
- VIRUS AETIOLOGY OF BEHCET'S SYNDROMEBritish Journal of Ophthalmology, 1964
- RECURRENT APHTHOUS ULCERATION OF ORAL MUCOUS MEMBRANE AND GENITALS ASSOCIATED WITH RECURRENT HYPOPYON IRITIS (BEHCET'S SYNDROME), REPORT OF THREE CASESBritish Journal of Dermatology, 1946