Preparation of spherical encapsulation of activated carbons and their adsorption capacity of typical uremic toxins

Abstract

A method has been designed for making spherical microencapsulation of activatedcarbon particles for use in the removal of metabolic wastes and/or toxins from blood. This bench‐scale method was able to make better uniformity in particle size, and at a higher particle production rate. The material properties such as particle size, particle porosity, electromicroscopy of surface morphology, surface hardness, and pore‐size distribution were characterized in order to conclude with their adsorption capacity for specific toxin solutes. The performance characteristics of these self‐prepared particle encapsulation was also evaluated against the commercially available hemoperfusion particles, e.g., Kuraray's DHP (Japan). The encapsulation particles were also coated with polyhydroxyethyl methacrylate (PHEMA) for blood compatibility purpose.