Photodimer of Thymine in Ultraviolet-Irradiated DNA: Proof of Structure by X-ray Diffraction
- 28 June 1968
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 160 (3835), 1451-1452
- https://doi.org/10.1126/science.160.3835.1451
Abstract
Dimethylthymine was photodimerized with ultraviolet radiation, and the structure of one of the resulting dimers, the cis 5,5 : 6,6 isomer, was determined by single-crystal x-ray diffraction. This isomer is the same as that obtained by ultraviolet irradiation of DNA; hence the structure of the thymine dimer in irradiated DNA is now proved.Keywords
This publication has 7 references indexed in Scilit:
- The crystal structure of a thymine photodimer (“thymer E”)Tetrahedron Letters, 1967
- Characterization of the photodimers from DNABiochemical and Biophysical Research Communications, 1967
- cis-syn Thymine Homodimer from Ultraviolet Irradiated Calf Thymus DNANature, 1967
- The symbolic addition procedure for phase determination for centrosymmetric and non-centrosymmetric crystalsActa Crystallographica, 1966
- Isolation and properties of isomeric thymine dimersBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1966
- On the nature of thymine photoproductBiochimica et Biophysica Acta, 1961
- The effect of ultraviolet light on some components of the nucleic acids. VI The origin of the U.V. sensitivity of deoxyribonucleic acidRecueil des Travaux Chimiques des Pays-Bas, 1960