Further Studies of the Beneficial Effect of Glutathione on X-irradiated Mice.

Abstract

2343 male, inbred Swiss albino mice were irradiated in a series of 4 expts. by the radial beam of a 2 MEV GE Industrial X-ray Unit. Lethal dose curves were determined simultaneously for the treated and untreated mice. Glutathione injn. prior to irradiation improves survival rate, decreases wt. loss, and reduces susceptibility to trauma of X-irradiated mice. Four mg. of glutathione per g. of mouse is roughly twice as effective as 16 mg./g. No protection was evident in the low lethal dose range (450-650 r).