Cell-mediated immunity in experimental Nocardia asteroides infection

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Abstract
Experimental mycetoma-like lesions developed in guinea pigs after s.c. injection of N. asteroides. Although delayed hypersensitivity appeared earlier, increased macrophage migration inhibition and microbicidal activity appeared after 7 wk. When the lesions healed, high cell-mediated immunity was present. Cell-mediated immunity was transferred to normal recipient guinea pigs from healed donor guinea pigs by spleen cell transfer. Recipient guinea pigs showed marked protection against challenge with N. asteroides.