Tetracycline-Resistant T-Mycoplasmas ( Ureaplasma urealyticum ) from Patients with a History of Reproductive Failure
Open Access
- 1 June 1976
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 9 (6), 1012-1018
- https://doi.org/10.1128/aac.9.6.1012
Abstract
The susceptibilities of T-mycoplasmas (Ureaplasma urealyticum) to minocycline, demeclocycline, doxycycline, tetracycline, and erythromycin were determined by a direct tube dilution test. T-mycoplasma-positive urine sediments of 105 patients with a history of reproductive failure were used as inocula. Minocycline was found to be the most active of the group of antibiotics commonly used to eradicate T-mycoplasma infection. Based on the median initial minimum inhibitory concentration, minocycline was the lowest with 0.03 μg/ml, followed by demeclocycline and doxycycline with 0.125 μg/ml, tetracycline with 0.25 μg/ml, and erythromycin with 2.0 μg/ml. Six T-mycoplasma isolates which had been cloned three times were also tested for susceptibility to the same five antibiotics. The same susceptibility pattern was found. Strains resistant to high concentrations of all antibiotics occurred. Strong positive correlation was seen in 21 patients between in vitro highly resistant strains and positive posttreatment cultures. These results indicate that empirical treatment of genital mycoplasma infections is not justified. Cultures should be taken pretreatment, susceptibility testing performed prior to treatment, and follow-up cultures done posttreatment.Keywords
This publication has 20 references indexed in Scilit:
- Non-specific urethritis associated with a tetracycline-resistant T-mycoplasma.Sexually Transmitted Infections, 1974
- T-mycoplasmas as a Possible Cause for Reproductive FailureNature, 1973
- TETRACYCLINE INHIBITION OF MYCOPLASMA RIBOSOMAL PROTEIN SYNTHESISThe Journal of Antibiotics, 1971
- ANTIBIOTIC RESISTANCE MECHANISMS IN MYCOPLASMA SPECIESThe Journal of Antibiotics, 1971
- Viability Of Mycoplasmas After Storage In Frozen Or Lyophilised StatesJournal of Medical Microbiology, 1970
- Absorption and Excretion of Five Tetracycline Analogues in Normal Young MenThe American Journal of the Medical Sciences, 1968
- Strain of Mycoplasma Associated with Human Reproductive FailureScience, 1967
- CULTIVATION AND PROPERTIES OF T‐STRAINS OF MYCOPLASMA ASSOCIATED WITH NONGONOCOCCAL URETHRITISAnnals of the New York Academy of Sciences, 1967
- THE CELL MEMBRANE OF MYCOPLASMA*Annals of the New York Academy of Sciences, 1967
- IMPORTANCE OF EXTENSION AND STANDARDIZATION OF LABORATORY TESTS FOR THE IDENTIFICATION AND CLASSIFICATION OF MYCOPLASMAAnnals of the New York Academy of Sciences, 1967