Arachidonic acid in splanchnic artery occlusion shock
- 1 July 1976
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 231 (1), 112-119
- https://doi.org/10.1152/ajplegacy.1976.231.1.112
Abstract
Arachindonic acid infused into the mesenteric vascular bed of normal pentobarbital-anesthetized dogs at a concentrations of 150 mug/kg per min produced no significant changes in mean arterial blood pressure (MABP), portal vein pressure (PVP), screen filtration pressure (SFP), platelet count, circulating lysosomal enzyme or myocardial depressant factor (MCF) activities, nad only modestly increased superior mesenteric arter flow (SMAF)ans endogenous prostaglandin concentrations concentrations. It is concluded that arachidonic acid, at the infusion rate employed, dose not have any major effect on the circulatory status or on the lysosomal or platelet stability in normal dogs. In contrast, arachidonic acid administered to dogs in splanchnic artery occulusion (SAO) shock significantly exacerbated the decline in MABP seen after release of the occlusive clamps and also significantly reduced mesenteric blood flow. The hypothnsive of arachidonic acid appears to be partly due to the fatty acid itself and partly due to the metavolically formed prostaglandin endoct the platelet count or aggregability, lysosomal hydrolase activity, or MDF formation in the SAO shock dogs. These data suggest that increased endogenous prostaglandin concentrations in themselves are not a prime factor in the pathophysiology of circulatory shock, but that endogenous prostaglandin or related substances can significantly modulate the shock state.This publication has 7 references indexed in Scilit:
- Characterization of a myocardial depressant factor present in hemorrhagic shockAmerican Journal of Physiology-Legacy Content, 1967
- CORTICOSTEROID ANTAGONISM OF POSITIVE INOTROPIC EFFECT OF OUABAIN1966
- Screen filtration pressure method and adhesiveness and aggregation of blood cellsJournal of Applied Physiology, 1964
- Morphology and Enumeration of Human Blood PlateletsJournal of Applied Physiology, 1950
- DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTIONJournal of Biological Chemistry, 1949
- CHROMOGENIC SUBSTRATES .2. PHENOLPHTHALEIN GLUCURONIC ACID AS SUBSTRATE FOR THE ASSAY OF GLUCURONIDASE ACTIVITY1946
- THE ESTIMATION OF CATHEPSIN WITH HEMOGLOBIN AND THE PARTIAL PURIFICATION OF CATHEPSINThe Journal of general physiology, 1937