Pulmonary Alveolar Hypoxia: Release of Prostaglandins and Other Humoral Mediators
- 27 September 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 185 (4157), 1181-1183
- https://doi.org/10.1126/science.185.4157.1181
Abstract
Hypoxic ventilation of isolated perfused cat lungs caused the frequent appearance in pulmonary perfusates of biologically active substances, which included prostaglandins or prostaglandin-like compounds. In anesthetized cats, inhibition of prostaglandin biosynthesis with infusions of aspirin (more than 50 milligrams per kilogram) reduced the pulmonary vasoconstrictor and bronchoconstrictor responses to hypoxic breathing.Keywords
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