Formulation and pharmacological studies of a controlled release pentagastrin injection
- 1 December 1970
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 22 (12), 923-929
- https://doi.org/10.1111/j.2042-7158.1970.tb08474.x
Abstract
Four formulations were designed to release pentagastrin at different rates after subcutaneous injection. These formulations were tested in vitro for rate of diffusion across a dialysis membrane into pH 7·3 phosphate buffer, and in vivo in rats for rate of excretion in the bile and on dogs for pharmacological responses. Good agreement was observed between the in vitro data, elimination rate and dose response data for the rate of release and duration of action of the four formulations. The results agreed with the theory that by controlling the rate of release of a short acting drug, one could sustain the pharmacological response to the drug and increase the total response by better utilization of an administered dose.Keywords
This publication has 5 references indexed in Scilit:
- Biopharmaceutical Considerations in Subcutaneous and Intramuscular Drug AdministrationJournal of Pharmaceutical Sciences, 1968
- The Effect of I.C.I. 50,123 (Pentapeptide) on Acid Secretion in ManScandinavian Journal of Gastroenterology, 1967
- EFFECTS OF A GASTRIN-LIKE PENTAPEPTIDE (I.C.I. 50,123) ON STOMACH AND PANCREASThe Lancet, 1966
- Structure–Function Relationships in the Active C-Terminal Tetrapeptide Sequence of GastrinNature, 1965
- The Determination of Absorption Rates from Rat Muscles: an Experimental Approach to Kinetic DescriptionsActa Pharmacologica et Toxicologica, 1964