Subcategories of histiocytic lymphoma: Associations with survival and reproducibility of classification. The southeastern cancer study group experience
- 1 December 1981
- Vol. 48 (11), 2464-2474
- https://doi.org/10.1002/1097-0142(19811201)48:11<2464::aid-cncr2820481120>3.0.co;2-4
Abstract
Five pathologists reviewed histologic slides from 134 cases of histiocytic lymphoma and subclassified these cases using the Lukes-Collins classification system. Of 98 morphologically subclassifiable cases, 85 were distributed among three categories, each presumed to represent a lymphoma of follicular center cell origin. The remaining 12 cases were classified among three additional categories. The cases within the three follicular center cell categories, considered collectively, had a significantly better survival than did the cases within the other three categories considered as a whole. The pathologists classified cases generally as being of a follicular center cell type with a high degree of reproducibility, but their individual classifications varied significantly with respect to more specific morphologic categories. Suboptimal quality of histologic sections was a significant factor contributing to problems in morphologic classification. Ancillary immunologic techniques may be required for definitive subclassification of large cell lymphomas.This publication has 13 references indexed in Scilit:
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