Induced Hypersensitivity to Barbital in the Female Rat
- 22 September 1967
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 157 (3795), 1463-1464
- https://doi.org/10.1126/science.157.3795.1463
Abstract
Female rats, treated with two daily anesthetic doses of barbital, exhibit 1 month later a significant increase in sleeping time over that of control animals. Hypersensitive animals, as compared to controls, show no alteration in liver weight (as percentage of body weight), but they manifest a significant shortening of time for induction of anesthesia. Induced hypersensitivity to barbiturates is apparently not the result of alterations in the metabolism of these agents, but it may be related to enhanced susceptibility of the central nervous system to these drugs.This publication has 5 references indexed in Scilit:
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- QUANTITATIVE ASPECTS OF TOLERANCE AND POSTTOLERANCE HYPERSENSITIVITY TO PENTOBARBITAL IN RAT1965
- Distribution and metabolism of barbital-14C in tolerant and nontolerant ratsBiochemical Pharmacology, 1964
- BARBITAL-C14 IN CAT + MOUSE1964
- STIMULATORY EFFECT OF CHLORCYCLIZINE ON BARBITURATE METABOLISM1961