Synthesis of Dithioacetals from Carbonyl Compounds and Thiols in the Presence of Polyphosphoric Acid Trimethylsilyl Ester (PPSE)

Abstract

Dithioacetals were synthesized from carbonyl compounds and thiols in the presence of polyphosphoric acid trimethylsilyl ester (PPSE) Aldehydes, Ketones, and trioxane could be used as carbonyl compounds, and aromatic, primary, secondary, and tertiary thiols were applicable in the present reaction. The reaction between cyclohexanone and t-butyl thiol afforded a mixture of corresponding dithioacetal and t-butylcyclohexenylsulfide.