The detection of non-adherence by self-administered questionnaires can be optimized by protease inhibitor plasma concentration determination
- 1 May 2003
- journal article
- Published by Wolters Kluwer Health in AIDS
- Vol. 17 (7), 1096-1099
- https://doi.org/10.1097/00002030-200305020-00025
Abstract
Self-reported adherence and plasma protease inhibitor concentration (PPIC) were assessed in 642 HIV-infected patients at month 4 of a single protease inhibitor-containing regimen. PPIC was below the limit of quantification (LOQ) in 32% of non-adherent patients and in 8% of adherent patients. The relationship between non-adherence and a detectable HIV viral load was enhanced when adherent patients with PPIC below LOQ were considered to be non-adherent. PPIC combined with self-report may more reliably detect non-adherence.Keywords
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