The Response of Metastatic Retroperitoneal Seminoma to Chemotherapy

Abstract

Two patients with advanced metastatic seminoma were treated with radiation therapy, triple drug chemotherapy and radical surgical resection. In 1 patient the seminoma was radiation recurrent and radiation resistant, while in the 2nd patient the metastatic seminoma encroached upon both kidneys and could not be irradiated initially for fear of bilateral radiation nephritis. Both tumors were reduced in size markedly by chemotherapy and the residual mass was excised in each instance. One patient was free of the tumor 18 mo. after treatment, while the other patient had recurrence in a distant area after 16 mo. The marked responsiveness of both tumors to triple drug chemotherapy emphasizes the importance of an aggressive approach to advanced metastatic seminoma, including radiation therapy, chemotherapy and surgery.