Unique DNA repair properties of a xeroderma pigmentosum revertant.
Open Access
- 1 September 1987
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 7 (9), 3353-3357
- https://doi.org/10.1128/mcb.7.9.3353
Abstract
A group A xeroderma pigmentosum revertant with normal sensitivity was created by chemical mutagenesis. It repaired (6-4) photoproducts normally but not pyrimidine dimers and had near normal levels of repair replication, sister chromatid exchange, and mutagenesis from UV light. The rate of UV-induced mutation in a shuttle vector, however, was as high as the rate in the parental xeroderma pigmentosum cell line.This publication has 39 references indexed in Scilit:
- Biological and biochemical consequences of the human ERCC-1 repair gene after transfection into a repair-deficient CHO cell lineMutation Research/DNA Repair Reports, 1987
- Removal of O6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid linesNature, 1981
- Repair of UV-endonuclease-susceptible sites in the 7 complementation groups of xeroderma pigmentosum a through GMutation Research, 1979
- Excision repair of ultraviolet damage in mammalian cells. Evidence for two steps in the excision of pyrimidine dimersBiophysical Journal, 1978
- Xeroderma pigmentosum neurological abnormalities correlate with colony-forming ability after ultraviolet radiation.Proceedings of the National Academy of Sciences, 1978
- Specific action of T4 endonuclease V on damaged DNA in xeroderma pigmentosum cells in vivo.Proceedings of the National Academy of Sciences, 1977
- Cross-link repair in human cells and its possible defect in Fanconi's anemia cellsJournal of Molecular Biology, 1977
- Transfer of purified herpes virus thymidine kinase gene to cultured mouse cellsCell, 1977
- Colony-forming ability of ultraviolet-irradiated xeroderma pigmentosum fibroblasts from different DNA repair complementation groupsBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1976
- Two forms of repair in the DNA of human cells damaged by chemical carcinogens and mutagens.1974