Oxetanes as Versatile Elements in Drug Discovery and Synthesis
Top Cited Papers
- 28 October 2010
- journal article
- review article
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 49 (48), 9052-9067
- https://doi.org/10.1002/anie.200907155
Abstract
Sizable resources, both financial and human, are invested each year in the development of new pharmaceutical agents. However, despite improved techniques, the new compounds often encounter difficulties in satisfying and overcoming the numerous physicochemical and many pharmacological constraints and hurdles. Oxetanes have been shown to improve key properties when grafted onto molecular scaffolds. Of particular interest are oxetanes that are substituted only in the 3‐position, since such units remain achiral and their introduction into a molecular scaffold does not create a new stereocenter. This Minireview gives an overview of the recent advances made in the preparation and use of 3‐substituted oxetanes. It also includes a discussion of the site‐dependent modifications of various physicochemical and biochemical properties that result from the incorporation of the oxetane unit in molecular architectures.Keywords
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