Baumycins, new antitumor antibiotics related to daunomycin.

Abstract

Antimicrobial activities of baumycins described were tested by the broth dilution method and the results are shown. Baumycins A1, A2, C1 and C2 showed a strong inhibition against Gram-positive bacteria, while baumycins B1 and B2 showed only weak activity. Baumycins A1 and A2 showed a strong inhibition against the growth and syntheses of RNA and DNA of cultured L1210 mouse leukemia cells: RNA synthesis inhibition (%) at 0.5 .mu.g/ml, A1, 64.7; A2, 60.6; B1, 17.6; B2, 14.3: DNA synthesis inhibition (%) at 1 .mu.g/ml, A1, 69.6; A2, 40.4; B1, 25.0; B2, 6.7.