Superiority of developed over total pressure for heart contractility indices in dogs

Abstract

Summary The independence of indices of contractility to Starling effects was tested in 6 closed-chest dogs. After vagal and beta-receptors blockade, indices calculated with total left ventricular isometric pressure (TP), were shown to be strongly dependent of rises in end-diastolic pressure (LVEDP) induced by dextran infusion. At LVEDP of 14.6±1.5, 22.2±1.1 and 32.8±1.5 mm Hg (±SEM), the peak value of velocity of the contractile elements calculated with total pressure (peak V_{CE, TP}) diminished by 21, 40 and 50%, and the extrapolated value of V_{CE, TP} at zero total pressure (V_{max, TP}) diminished by 15, 30 and 44%. In contrast, indices calculated with developed pressure (DP=TP-LVEDP) at the same LVEDP were much less influenced, particularly the extrapolated value of V_{CE, DP} at zero DP (V_{max, DP5}) and (peakdP/dt)/DP did not significantly change. During angiotensin infusion, expected decreases in TP indices secondary to LVEDP rises were partially masked by simultaneous increases in contractility, and DP indices tended to rise. On the other hand, with minimal changes in LVEDP, as during calcium injection and paired stimulation, increases in TP and DP indices demonstrate inotropic effects equally well. Our study also shows that, besides V_max calculated with DP, the instantaneous ratio of peakdP/dt and DP can also be proposed as a simpler and thus more convenient index of contractility independent of volume changes.