Experimental Steatorrhea Induced in Man by Bile Acid Sequestrant.

Abstract

Gross streatorrhea in otherwise normal human subjects was induced by administration in appropriate dosage of a resin capable of sequestering bile acids in the intestinal lumen. This agent (MK-135) inhibited the absorption of I131-labeled triolein but not I131-oleic acid. Studies suggest that the mechanism of resin-induced steatorrhea is related to exclusion of bile acids from participation in hydrolytic digestion of dietary triglyceride. In contrast to certain other forms of experimental malabsorption, MK-135-induced steatorrhea appears to be predictable and innocuous.