Does presynaptic regulation of sympathetic transmission occur within a limited range of neuronal activity?
- 30 September 1982
- journal article
- research article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 321 (1), 77-79
- https://doi.org/10.1007/bf00586354
Abstract
Recent reports indicate that the presynaptic negative feedback mechanism involved in regulating sympathetic neurotransmission is only functional within a narrow range of neuronal activity. The specific aim of this report is to examine the release of sympathetic transmitter at varying frequencies of stimulation, and the effects of α-adrenoceptor antagonists on the overflow. The experiments were carried out in the3H-noradrenaline-labeled heart of the guinea pig. The overflow of tritium (per pulse) increased from a stimulation frequency of 0.125 to 10 Hz and declined at 30 Hz. Phentolamine or yohimbine produced facilitation of the overflow from 0.125 to 10 Hz; the effect was more pronounced at lower frequencies of stimulation. We conclude that the presynaptic α-adrenoceptor-mediated negative feedback mechanism operates over a wide range of cardiac sympathetic nerve activity.Keywords
This publication has 19 references indexed in Scilit:
- Release of noradrenaline by one pulse: Modulation of such release by alpha-adrenoceptor antagonists and uptake blockersNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1981
- Conditions required for the inhibitory feedback loop in noradrenergic transmissionNature, 1981
- A kinetic analysis of the extraneuronal uptake and metabolism of catecholaminesReviews of physiology, biochemistry and pharmacology, 1979
- Inhibition of noradrenaline release by adenosine.The Journal of Physiology, 1978
- Frequency-Dependence of3H-Noradrenaline Secretion from Human Vasoconstrictor Nerves: Modification by Factors Interfering with α- or β-Adrenoceptor or Prostaglandin E2Mediated ControlActa Physiologica Scandinavica, 1977
- Preferential blockade of presynaptic α-adrenoceptors by yohimbineEuropean Journal of Pharmacology, 1975
- Pre- and postsynaptic components in effect of drugs with α adrenoceptor affinityNature, 1975
- Alpha-adrenoceptor Mediated Feed-back Control of Sympathetic Neurotransmitter Secretion in Guinea-pig Vas DeferensNature New Biology, 1973
- Influence of extracellular noradrenaline on the stimulation-evoked secretion of noradrenaline from sympathetic nerves: Evidence for an ?-receptor-mediated feed-back inhibition of noradrenaline releaseNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1972
- A muscarinic inhibition of the noradrenaline release evoked by postganglionic sympathetic nerve stimulationNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1969