MACROMOLECULAR INHIBITORY FACTOR FOR LYMPHOID-CELLS PRODUCED BY MOUSE MACROPHAGES
- 1 January 1977
- journal article
- research article
- Vol. 33 (3), 391-398
Abstract
Supernatants of high density cultures of mouse peritoneal macrophages were inhibitory to homologous lymphoid cells in vitro by a number of parameters: proliferation and survival of [mouse L1210(A)] lymphoma cells was impaired, the immune response of spleen cells to sheep red cells and to concanavalin A (Con A) was decreased. Inhibition was due to a factor(s) with MW of .apprx. 110,000 as estimated by gel filtration. Activity was stable to heating at 56.degree. C, and was resistant to trypsin but not to pronase.This publication has 23 references indexed in Scilit:
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