The usability of the MRL/1 mouse strain in detection of anti-rheumatic drugs
- 1 December 1984
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 15 (5-6), 578-583
- https://doi.org/10.1007/bf01966777
Abstract
D-Penicillamine (5 mg/kg), prednisolone (0.5 mg/kg), tolfenamic acid and thiabendazole (10 mg/kg) were chronically administered to male and female mice of MRL/l strain. The treatment was started either at 4 weeks of age (prophylactic dosing) or at 12 weeks of age (therapeutic dosing) and continued until the termination at 24 weeks of age. In male mice all the drugs caused a significant retardation in IgM-RF formation with one of the dosing regimes.d-Penicillamine and prednisolone also had an inhibitory effect on lymph node enlargement. In female mice, however, only thiabendazole retarded the RF activity significantly. None of the drugs had any marked effect on anti-ssDNA antibody formation, and none of the treatments affected the development of renal disease or modified the survival of these mice.This publication has 24 references indexed in Scilit:
- Models of arthritis and the search for anti-arthritic drugsPharmacology & Therapeutics, 1983
- Thymic Influences on Autoimmunity in MRL‐1pr MiceScandinavian Journal of Immunology, 1982
- A spontaneous rheumatoid arthritis-like disease in MRL/l mice.The Journal of Experimental Medicine, 1982
- Adjuvant polyarthritis in rats: is this a satisfactory model for screening anti-arthritic drugs?Inflammation Research, 1982
- Thiabendazole (TBZ), an immunohemomodulator II. Effects on thymocytes and prothymocytesInternational Journal of Immunopharmacology, 1982
- Thiabendazole (TBZ), an immunohemomodulator I. Effects on lymph node and spleenInternational Journal of Immunopharmacology, 1982
- Approach to the study of the role of sex hormones in autoimmunityArthritis & Rheumatism, 1979
- Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains.The Journal of Experimental Medicine, 1978
- Preparation of Enzyme‐labelled Staphylococcal Protein A and its Use for Detection of AntibodiesScandinavian Journal of Immunology, 1978
- Androgenic Hormones Modulate Autoantibody Responses and Improve Survival in Murine LupusJCI Insight, 1977