METABOLISM OF POLYCYCLIC COMPOUNDS. THE METABOLISM OF 7,12-DIMETHYLBENZ[α]ANTHRACENE BY RAT-LIVER HOMOGENATES
- 1 June 1965
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 95 (3), 780-787
- https://doi.org/10.1042/bj0950780
Abstract
The main products of the metabolism of 7, 12-dimethylbenz[a]anthracene by rat-liver homogenates are the isomeric monohydroxymethyl derivatives. The syntheses of these compounds are described. Two phenolic products and 2 dihydrodihydroxy compounds were formed, but none of these appeared to have been formed by hydroxylation at the ''K region''. There was little evidence for the formation of a glutathione conjugate of the hydrocarbon. The monohydroxymethyl derivatives are products of the hydroxylation of the hydrocarbon in the ascorbic acid-Fe2+-oxygen model hydroxylating system.Keywords
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