THE INFLUENCE OF GLYCOTROPIC SUBSTANCES ON SURVIVAL OF THE PRIMITIVE RESPIRATORY CENTER IN THE ISCHEMIC RAT HEAD

Abstract

Glycotropic substances affecting survival time, duration and number of gasps of the decapitated rat head are adrenaline, insulin, iodoacetie acid, anterior and posterior pituitary extracts, and ephedrine. Starvation modifies the results of these substances as less glucose becomes available. An additional series of gasps appears after adrenaline inj. The delayed period of gasps is entirely abolished in starved animals treated with insulin or iodoacetie acid indicating the anaerobic nature of this series of gasps. Aqueous extracts of ant. or post. pituitary gland greatly prolong the survival time showing effects qualitatively similar. Survival time is increased by adrenaline, anterior or posterior pituitary, but shortened by ephedrine, insulin, and iodoacetic acid.