Interferon Therapy for Laryngeal Papillomatosis in Adults
- 1 August 1983
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Otolaryngology–Head & Neck Surgery
- Vol. 109 (8), 550-552
- https://doi.org/10.1001/archotol.1983.00800220056014
Abstract
• Eight patients with recurrent laryngeal papillomatosis were treated with exogenous leukocyte interferon α, 1 to 4 × 106 IU daily or every second day for 150 days. During an initial three-week period of low-dose treatment, tumor size was reduced in five patients. After three weeks of treatment, microsurgical removal was performed, followed by increased dosage of interferon. At the end of the five-month treatment, recurrence of small papillomas was found in one of the patients. During the posttreatment period (seven to 11 months), recurrences occurred in four patients. We conclude from this pilot study that exogenous leukocyte interferon changes the pattern of recurrences of laryngeal papillomas in adults and may supplement surgical treatment. (Arch Otolaryngol 1983;109:550-552)This publication has 4 references indexed in Scilit:
- Interferon Therapy in Juvenile Laryngeal PapillomatosisJAMA Otolaryngology–Head & Neck Surgery, 1981
- Toxicity of interferon.BMJ, 1981
- Large-scale Production of Human Leukocyte Interferon Containing 108 Units per mlJournal of General Virology, 1978
- Human Papillomaviruses and Their Possible Role in Squamous Cell CarcinomasPublished by Springer Nature ,1977