Not since therapy with the sulfonamide compounds was introduced has there been any therapeutic agent as completely studied as penicillin. The startling and almost miraculous results obtained by the use of this agent in the treatment of gonorrhea, meningitis, syphilis and septicemia are well known. It is our purpose to review the results obtained in the treatment of some cutaneous diseases with penicillin locally and parenterally administered. The penicillin obtained was the dry, amorphous, yellowish form, and its sodium salt was the preparation used clinically. The solution employed contained 400 to 600 Oxford units per cubic centimeter. This was applied to the affected areas as a wet dressing, so that the lesions were constantly dampened with the penicillin solution. To prevent the solution from evaporating rapidly, the saturated gauze was well covered with oilcloth. For the intramuscular injections, 20,000 units of penicillin was mixed