Screening strategies based on solubility and solution composition generate pharmaceutically acceptable cocrystals of carbamazepine
- 20 March 2008
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in CrystEngComm
- Vol. 10 (7), 856-864
- https://doi.org/10.1039/b715396a
Abstract
Four different screening techniques were used to form cocrystals of carbamazepine containing pharmaceutically acceptable carboxylic acids. Twenty-seven unique solid phases utilizing eighteen carboxylic acid coformers were generated in the screening experiments. Cocrystal formation and stability in water is reported. Phase solubility diagrams and triangular phase diagrams are used to illustrate how saturation of the reactants leads to supersaturation of the cocrystal.Keywords
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