EFFECT OF THE ANGIOTENSIN II ANTAGONIST SARALASIN ON PLASMA ALDOSTERONE CONCENTRATION AND ON BLOOD PRESSURE BEFORE AND DURING SODIUM DEPLETION IN NORMAL SUBJECTS
- 1 March 1979
- journal article
- research article
- Published by Wiley in Clinical Endocrinology
- Vol. 10 (3), 227-234
- https://doi.org/10.1111/j.1365-2265.1979.tb02076.x
Abstract
The effect of the angiotensin II antagonist saralasin on plasma aldosterone, plasma angiotensin II and blood pressure was studied in 6 normal supine subjects both before and during Na depletion. Before Na depletion, infusion of saralasin produced no consistent changes; during Na depletion, infusion of the angiotensin antagonist caused a fall in plasma aldosterone and an increase in plasma angiotensin II in each subject. Angiotensin II plays a major part in stimulating aldosterone secretion during Na depletion in man.This publication has 19 references indexed in Scilit:
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