SYNAPTOSOMAL UPTAKE AND RELEASE OF DOPAMINE AND 5-HYDROXYTRYPTAMINE IN THE NUCLEUS ACCUMBENS INVITRO FOLLOWING INVIVO ADMINISTRATION OF LYSERGIC-ACID DIETHYLAMIDE IN RATS
- 1 January 1980
- journal article
- research article
- Vol. 39 (8-9), 889-895
Abstract
The uptake and the depolarization-induced release of dopamine (DA) and serotonin (5-HT) were investigated after systemic application of LSD on synaptosomes of the nucleus accumbens of rats. For the release experiments synaptosomes were prelabeled with [14C]-DA and [3H]-5-HT and superfused with physiological and potassium enriched (50 mM) solutions. Low doses of LSD (0.1 and 0.5 mg/kg i.p.) induced a dose dependent inhibition of the DA-release and an increase of the DA-uptake. LSD inhibited the release and the uptake of 5-HT significantly. The results are discussed with respect to a reliable characterization of the in vivo induced effects of LSD on the isolated synaptosomes.This publication has 10 references indexed in Scilit:
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