Initiation of Human Parturition
- 1 March 1978
- journal article
- research article
- Published by Wolters Kluwer Health in Obstetrics & Gynecology
- Vol. 51 (3), 278-280
- https://doi.org/10.1097/00006250-197803000-00004
Abstract
Inin vitrostudies it was found that, in the presence of added NADPH, the human placenta metabolizes progesterone to 20α-hydroxy-4-pregnen-3-one at increasing rates as pregnancy advances. A fivefold increase in 20α-hydroxysteroid oxidoreductase activity is observed in term placentas compared with the enzymic activity of placentas of 12 to 20 weeks' gestation (368 ± 53 pmoles/mg protein/hr vs 71 ± 8 pmoles/mg protein/hr). The 5α-reductase and 3β-hydroxysteroid oxidoreductase activities were similar in placentas obtained from early and late human pregnancies.This publication has 6 references indexed in Scilit:
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- INITIATION OF HUMAN PARTURITION .8. METABOLISM OF PROGESTERONE BY FETAL MEMBRANES OF EARLY AND LATE HUMAN GESTATION1977
- Initiation of human parturitionAmerican Journal of Obstetrics and Gynecology, 1976
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