Effect of Prostaglandin Synthetase Inhibitors on Pressor Response to Angiotensin II in Human Pregnancy*
- 1 June 1978
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 46 (6), 1007-1010
- https://doi.org/10.1210/jcem-46-6-1007
Abstract
Pregnant women destined to develop pregnancy-induced hypertension (PIH) lose refractorinessto the pressor effects of infused angiotensin II (AII) several weeks before the onset of hypertension. This loss of refractoriness to A-II is unrelated to plasma renin activity or circulating levels of A-II. In animal studies it has been shown that the prostaglandins are important mediators of vascular reactivity. Specifically, the uterine blood flow appears to vary directly with prostaglandin E concentrations in uterine venous effluent. The present study was designed to evaluate the effects of prostaglandin synthetase inhibitors on the pressor effects of A-II in human pregnancy. The “effective A-II pressor dose” (nanograms of A-II·kg-1·min-1 necessary to cause a 20 mm Hg rise in diastolic pressure) was determined in 14 pregnant women before and after treatment with either 25 mg indomethacin or 600 mg aspirin given twice, 6 h apart. The effective pressor dose required before treatment [22.7 ± 3.4 ng·kg-1·min-1 (mean ± SE)] was significantly greater than that after treatment [8.7 ± 1.2ng·kg-1·min-1 (P¼0.001)]. The refractoriness to A-II observed in normal human pregnancy may be mediated in part by the action of prostaglandins or related substances produced in the arteriole.Keywords
This publication has 4 references indexed in Scilit:
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- The supine hypertensive test as a predictor of incipient pre-eclampsiaAmerican Journal of Obstetrics and Gynecology, 1977
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