Mathematical basis and generalization of the Loo-Riegelman method for the determination ofin vivo drug absorption

Abstract

A general numerical deconvolution method is derived for the determination of in vivodrug input functions. The derivation is based on linear interpolation of observed drug concentrations and deconvolution of the resulting trapezoidal function. Derived in vivoinput functions are discontinuous. A general expression for the cumulative drug input is also derived. The latter expression is a generalization of the Loo-Riegelman equations. This deconvolution method gives similar results to the “point-area” deconvolution method when deriving in vivodrug input functions.